Synthesis and functional analysis of novel biologically active molecules based on complex macrolide natural products

2016 Fiscal Year Final Research Report

• Project/Area Number: 25282228
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biomolecular chemistry
• Research Institution: Tohoku University
• Principal Investigator: Sasaki Makoto 東北大学, 生命科学研究科, 教授 (80235267)
• Co-Investigator(Renkei-kenkyūsha): FUWA Haruhiko 東北大学, 大学院生命科学研究科, 准教授 (90359638)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 海洋天然物 / マクロリド / 全合成 / 生体機能分子 / 機能解析

Outline of Final Research Achievements

Our research focused on the efficient total synthesis of structurally complex marine macrolide natural products with significant biological activities to investigate and exploit their biological functions. A convergent synthesis of a fully functionalized macrolactone core of goniodomin A, a polyether macrolide that targets actin cytoskeleton, has been accomplished. An efficient, convergent total synthesis of polycavernoside B, a lethal glycosidic macrolide isolated from the red alga, has been achieved for the first time. In addition, efficient synthetic routes to the C1-C13 and C8-C29 fragments of amphidinolide N, an extremely potent cytotoxic macrolide, have been developed in a convergent manner.

Free Research Field

天然物合成化学