2015 Fiscal Year Final Research Report
Roles of endogenous small molecule in autophagy induction
| Project/Area Number |
25282236
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | オートファジー / 細菌感染 / 8-ニトロcGMP |
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| Outline of Final Research Achievements |
Autophagy is a major intracellular degradation system that serves to maintain homeostasis and to suppress disease progression. Majority of autophagy processes are believed to be non-selective but there are some exceptions. These selective autophagy processes must have different mechanism from canonical autophagy. We have examined in this study whether endogenous small molecules are involved in the selection mechanism. Under the inflammation conditions by bacterial infection, a nitrated nucleotide: 8-nitro-cGMP forms in the host cells. I found this nucleotide accumulated around the invading bacteria cells (group A streptococcus) and this accumulation was found to be an early marker for selective autophagic degradation of the bacterial cells.
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| Free Research Field |
ケミカルバイオロジー
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