2015 Fiscal Year Final Research Report
Development of RNA medicine based on nano-structured design and templated reaction
| Project/Area Number |
25282240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Nagoya University (2015)
Hokkaido University |
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Principal Investigator |
ABE HIROSHI 名古屋大学, 理学(系)研究科(研究院), 教授 (80415067)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | RNA / 化学反応 / 免疫応答 / RNA干渉 |
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| Outline of Final Research Achievements |
We developed a new strategy for the buildup reaction of active siRNA species from short RNA fragments in living cells using a chemical ligation reaction. This strategy could decrease undesired immune responses and provide more latitude for RNAi technology in the design and concentration of introduced RNA compared to traditional siRNA methods.
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| Free Research Field |
核酸化学
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