Analysis of cerebral network in psychiatric disease cases

2017 Fiscal Year Final Research Report

• Project/Area Number: 25282250
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Brain biometrics
• Research Institution: Tokai University
• Principal Investigator: MIZUTANI Ryuta 東海大学, 工学部, 教授 (70272482)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Yoshio 公益財団法人高輝度光科学研究センター, 利用研究促進部門, 副主席研究員 (20372146) ; TAKEKOSHI Susumu 東海大学, 医学部, 教授 (70216878) ; ITOKAWA Masanari 公益財団法人東京都医学総合研究所, 病院等連携研究センター, センター長 (40332324)
• Research Collaborator: SAIGA Rino
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: マイクロトモグラフィ / ナノトモグラフィ / 統合失調症 / 脳 / 三次元構造

Outline of Final Research Achievements

Psychiatric symptoms of schizophrenia suggest alterations of cerebral neurons. However, the physical basis of schizophrenia has not been delineated. In this study we analyzed tissue structures of the anterior cingulate cortex of schizophrenia and control cases with nanotomography at SPring-8 and at Advanced Photon Source of Argonne National Lab. Tissue constituents visualized in the 3D images were traced to build Cartesian coordinate models of neurons. Neurite geometries were then evaluated by calculating the curvature and torsion from the Cartesian coordinates. The obtained results indicated that neuronal structures are different between individuals, and those differences become extraordinary in schizophrenia. The anterior cingulate cortex is considered responsible for cognitive functions including decision making. The geometrical alteration identified in this study should reflect psychiatric symptoms of schizophrenia.

Free Research Field

構造生物学