Capsule like-assembly of magnetic nanoparticles enabling the drug release by radio wave irradiation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25286001
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Nanostructural chemistry
• Research Institution: Hokkaido University
• Principal Investigator: Niikura Kenichi 北海道大学, 電子科学研究所, 准教授 (40360896)
• Co-Investigator(Renkei-kenkyūsha): NINOMIYA Takafumi 札幌医科大学, 医学部, 准教授 (80156140)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 自己組織化 / ナノ粒子 / 刺激応答性 / 階層構造 / 磁性粒子 / 金ナノ粒子

Outline of Final Research Achievements

In this research, to develop stimuli-responsive drug delivery carriers, we explored surface ligand molecules that can induce the self-assembly of metallic nanoparticles, such as magnetic or gold nanoparticles in solutions. It was found that surface modification with a ligand molecule possessing a fluorinated oligoethylene glycol (SFL) induced spherical self-assembly of magnetic nanoparticles as well as gold nanoparticles. Interestingly, the glucose-terminated SFL molecules enabled the formation of size-segregated structures when used with a mixture of gold nanoparticles of two different diameters. Gold nanoparticles showing thermal responsiveness were also successfully created.

Free Research Field

コロイド・界面化学・生体機能