Fabrication of ship-in-a-bottle biochips by hybrid femtosecond laser processing

2015 Fiscal Year Final Research Report

• Project/Area Number: 25286038
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Nano/Microsystems
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: SUGIOKA Koji 国立研究開発法人理化学研究所, 光量子工学研究領域, ユニットリーダー (70187649)
• Co-Investigator(Kenkyū-buntansha): WU Dong 国立研究開発法人理化学研究所, 光量子工学研究領域, 国際特別研究員 (50618775)
• Co-Investigator(Renkei-kenkyūsha): KAWANO Hiroyuki 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (10332256)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 先端機能デバイス / マイクロナノデバイス / レーザー加工 / ナノマイクロファブリケーション / バイオチップ

Outline of Final Research Achievements

To fabricate a new type of biochips possessing high functionalities referred to as ship-in-a-bottle biochips, we developed hybrid femtosecond laser processing, in which three-dimensional (3D) glass micromachining and two-photon micro/nano polymerization were successively carried out. The developed technique allowed us to integrate multifunctional components into the 3D glass microfluidic structures for filtering microparticles and efficiently mixing two kinds of fluids in the microchannel at the same time. Furthermore, integration of a microlens array combined with center-pass units realized the ship-in-a-bottle biochip enabling parallel detection and counting of biological cells with the 100% success rate.

Free Research Field

レーザープロセシング