Cooperative Effect of Multi-Active Sites in Catalytic Reactions

2015 Fiscal Year Final Research Report

• Project/Area Number: 25288019
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: Tokyo University of Science (2015); Kanazawa University
• Principal Investigator: Endo Kohei 東京理科大学, 理学部, 准教授 (70454064)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 分子触媒 / 有機金属化学 / クラスター

Outline of Final Research Achievements

The present project for the development of multi-active sites in catalysis revealed the electrophilic activation by neighboring atoms for the activation of a reactive site. (1) The use of Fischer-type carbene complexes as electrophilic organometallic intermediates realized the tandem nucleophilic addition reaction. The use of stable cyclopropenes as carbene precursors provides a allylmetal intermediates via the reaction with organometallic reagents, followed by the tandem allylation reaction of appropriate electrophiles took place efficiently. (2) The multi-metallic catalysts achieved the asymmetric conjugate addition to give chiral furnaces bearing a quaternary stereogenic center. (3) The bimetallic cluster system showed unique chemo- and stereoselectivity in the reduction of alkynes using formic acid.

Free Research Field

有機化学