Reactivity and Selectivity of Hypochlorite Adducts of Metal Complexes

2016 Fiscal Year Final Research Report

• Project/Area Number: 25288032
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Inorganic chemistry
• Research Institution: Nara Women's University (2014-2016); Okazaki Research Facilities, National Institutes of Natural Sciences (2013)
• Principal Investigator: Fujii Hiroshi 奈良女子大学, 自然科学系, 教授 (80228957)
• Co-Investigator(Renkei-kenkyūsha): HADA Masahiko 首都大学東京, 理工学研究科, 教授 (20228480) ; OGURA Takashi 兵庫県立大学, 生命理学研究科, 教授 (70183770) ; ADACHI Shinichi 大学共同利用機関法人高エネルギー加速器機構, 物質構造科学研究所, 教授 (60260220)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: heme / salen / hypochlorite / chloroperoxidase / myeloperoxidase / chloride / oxidation / chlorination

Outline of Final Research Achievements

In this project, we studied how hypochlorious acid is produced from the reaction of a high-valent oxoiron complex with chloride. This study points out that the key factor to produce hypochlorious acid is the reactivity of the high-valent oxoiron intermediate that is controlled by unique coordination structures of the active sites in the enzymes. In addition, we studied how the reactivity of the hypochlorite adduct complex is controlled. The most important factor to control the reactivity of the complex is electron donor ability form the cis- and trans-ligands. Interestingly, the electron donor effect of these two ligands show different trend to the reactivity.

Free Research Field

生物無機化学