Improved phodynamic activity by control of position of fullerene derivatives in liposomes

2016 Fiscal Year Final Research Report

• Project/Area Number: 25288037
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Functional solid state chemistry
• Research Institution: Hiroshima University (2014-2016); Nara Institute of Science and Technology (2013)
• Principal Investigator: Ikeda Atsushi 広島大学, 工学(系)研究科(研究院), 教授 (90274505)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: フラーレン / リポソーム / ホスト-ゲスト錯体 / 光線力学治療

Outline of Final Research Achievements

An effective exchange method is described whereby liposomal drug carriers of
hydrophobic fullerene are used to incorporate the guests into lipid membranes. The exchange method transfers the fullerenefrom a cyclodextrin cavity to a liposome in water. I attempted [60]Fullerene (C60) derivatives were incorporated into liposomes using a fullerene exchange method, but failed. However, in the experiments, we found that (i) C60 derivatives have much higher photodynamic activity thatn C60 under photoirradiation at long wavelengths (>610 nm) and (ii) beta-1,3-glucan-complexed an anionic C60 derivative has higher photoactivity toward RAW cells than other C60 derivatives. Recently, I succeeded the preparation of lipid-membrane-incorporated C60 derivatives.

Free Research Field

超分子化学、有機合成化学