2016 Fiscal Year Final Research Report
Improved phodynamic activity by control of position of fullerene derivatives in liposomes
Project/Area Number |
25288037
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Functional solid state chemistry
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Research Institution | Hiroshima University (2014-2016) Nara Institute of Science and Technology (2013) |
Principal Investigator |
Ikeda Atsushi 広島大学, 工学(系)研究科(研究院), 教授 (90274505)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | フラーレン / リポソーム / ホスト-ゲスト錯体 / 光線力学治療 |
Outline of Final Research Achievements |
An effective exchange method is described whereby liposomal drug carriers of hydrophobic fullerene are used to incorporate the guests into lipid membranes. The exchange method transfers the fullerenefrom a cyclodextrin cavity to a liposome in water. I attempted [60]Fullerene (C60) derivatives were incorporated into liposomes using a fullerene exchange method, but failed. However, in the experiments, we found that (i) C60 derivatives have much higher photodynamic activity thatn C60 under photoirradiation at long wavelengths (>610 nm) and (ii) beta-1,3-glucan-complexed an anionic C60 derivative has higher photoactivity toward RAW cells than other C60 derivatives. Recently, I succeeded the preparation of lipid-membrane-incorporated C60 derivatives.
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Free Research Field |
超分子化学、有機合成化学
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