Development of novel catalysts inducing halogen bonding and its application for asymmetric synthesis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25288045
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: Norio Shibata 名古屋工業大学, 工学(系)研究科(研究院), 教授 (40293302)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: フッ素 / ハロゲン結合 / 試薬 / 電子吸引性 / 触媒

Outline of Final Research Achievements

The key for the development of novel molecules inducing halogen bonding is the introduction electron-deficient fluorinated functional group into the structures. Therefore I first studied the development of new reagents for fluoro-functionalized reagents. After investigation, we developed novel trifluoromethylthiolation reagent, pentafluorophenylation reagent, and pentafluorosulfanylphenyl reagent. In addition, I succeeded the design and synthesis of fluoro-functionalized phthalocyanines and subphthalocyanines. Furthermore, corresponding fluoro-functionalized subphthalocyanine shows the remarkable ability for catalytic trifluoromethylation under LED red light. Finally, I investigated the halogen-binding possibility of various compounds thoroughly and I found the novel catalyst for Mukaiyama-aldol reaction based on the halogen bonding.

Free Research Field

フッ素化学