MRI contrast agents for high relaxivity, kinetic stability, and targeting

2016 Fiscal Year Final Research Report

• Project/Area Number: 25288061
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Tohoku University
• Principal Investigator: Iki Nobuhiko 東北大学, 環境科学研究科, 教授 (50282108)
• Co-Investigator(Kenkyū-buntansha): 鈴木 敦子 (升谷敦子) 東北大学, 環境科学研究科, 助教 (10633464) ; 高橋 透 福井大学, 工学(系)研究科(研究院), 准教授 (30361166)
• Research Collaborator: CARAVAN Peter ハーバード医科大学, マサチューセッツ総合病院, 准教授
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: MRI / 緩和能 / 造影剤 / 金属錯体 / 速度論的安定性 / ターゲティング / イメージング

Outline of Final Research Achievements

In about 30% of magnetic resonance imaging (MRI), contrast agents (CAs) are used aiming at enhancing the sensitivity and contrast. Currently, Gd complexes of poly(aminocarboxylate) are commonly used, which however have limitation of sensitivity and side effects known as nephrogenic systemic fibrosis. Here we propose a new molecular motif of CA, Gd3TCAS2, on the basis of a complex of tri-Gd cluster sandwiched between two thiacalixarene (TCAS) ligands. In this study, we elucidated the formation behavior of the trinuclear complex, solution structure, relaxivity of Gd3TCAS2 to lead to design of new CA.

Free Research Field

分析化学