Analytical System for Imaging Mass Spectrometry using Gold Nanoparticles as a Mass Probe

2015 Fiscal Year Final Research Report

• Project/Area Number: 25288066
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Analytical chemistry
• Research Institution: Kagoshima University
• Principal Investigator: Niidome Yasuro 鹿児島大学, 学術研究院理工学域理学系, 准教授 (50264081)
• Co-Investigator(Kenkyū-buntansha): Niidome Takuro 熊本大学, 大学院自然科学研究科, 教授 (20264210)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 金ナノロッド / 質量分析 / マスプローブ / 質量分析イメージング

Outline of Final Research Achievements

Liver tissue sections were prepared from mice in which gold nanorods were intravenously injected. Desorption of Gold ions from a 20 micrometer-thick section was possible. Imaging mass spectrometry of gold ions revealed the distribution of gold nanoparticles in tumor tissues of tumor-bearing mice. Gold nanoparticles were find in the areas where blood flow existed. It was found that gold nanorods acted as a mass probe in a living body.
Very sensitive detection of gold ions desorbed from polymer membranes was possible. However, large scale aggregation of nanoparticles suppressed the ionization/desorption of gold ions. Individually isolated gold nanorods were found to act as an efficient mass probe.

Free Research Field

コロイド界面化学