2015 Fiscal Year Final Research Report
Creation of Novel Concerted Supramolecular Catalysts Utilizing Molecular Recognition Ability of Antibodies
| Project/Area Number |
25288082
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Green/Environmental chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Akira 大阪大学, 大学院理学研究科, 教授 (80127282)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | モノクローナル抗体 / タンパク質 / 不斉触媒 / キラル認識 / 遷移金属錯体 / 分子認識 |
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| Outline of Final Research Achievements |
Binaphthyl groups with axial chirality compose many chiral ligands (ex. BINAP) used in asymmetric synthesis. Preparation of monoclonal antibodies (MABs) specific for each optical isomer is thought to be appropriate to realize convenient chiral separation and asymmetric catalytic system. We obtained MABs specific for one of optical isomers of binaphthyl derivative (BN) by immunization with racemic mixture. One of the chiral isomers of BN could be separated with high e.e. by a simple procedure using the corresponding mAbs.
MABs which can bind not only rhodium complex but also palladium complex were obtained. The catalytic activity of the complex between monoclonal antibody with the palladium catalyst was examined. Allylic amination reaction was found to be catalyzed with high stereoselectivity by utilizing the MAB-palladium complex.
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| Free Research Field |
生体高分子化学
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