Application of thermo-sensitive complex containing photothermal conversion molecule, fullerene to cancer therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 25288101
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: University of Hyogo
• Principal Investigator: Yusa Shin-ichi 兵庫県立大学, 工学(系)研究科(研究院), 准教授 (00301432)
• Co-Investigator(Kenkyū-buntansha): 横山 昌幸 東京慈恵会医科大学, 医学部, 教授 (20220577) ; 白石 貢一 東京慈恵会医科大学, 医学部, 講師 (40426284) ; 藤井 秀司 大阪工業大学, 工学部, 准教授 (70434785) ; 岩崎 泰彦 関西大学, 工学部, 教授 (90280990)
• Co-Investigator(Renkei-kenkyūsha): YAMAGO Shigeru 京都大学, 化学研究所, 教授 (30222368)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 高分子 / 自己組織化 / ナノチューブ・フラーレン / 癌 / 高分子構造・物性 / 近赤外線 / ドラッグデリバリーシステム / 生体適合性高分子

Outline of Final Research Achievements

We have developed a method to dissolve hydrophobic fullerene (C60) which shows photothermal conversion effect in water. Thermo-responsive diblock copolymers which were prepared via a controlled radical polymerization method were used to dissolve C60 in water by complex formation of the diblock copolymer with C60. The C60 complex was consisted of C60-containing core and thermo-responsive shells. The size of the C60 complex increased due to inter-complexes aggregation with increasing temperature. In the future when the C60 complex is injected into the body, the complex may accumulate at tumor site by warming around the affected part. If light is irradiated to the affected part, the temperature of C60 increased to damage tumor site.

Free Research Field

高分子合成