2016 Fiscal Year Final Research Report
Experimental verification for regulation of production of inflammatory cytokine by surface texturing on load bearing in artificial joint
| Project/Area Number |
25289024
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Design engineering/Machine functional elements/Tribology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
三浦 裕正 愛媛大学, 医学(系)研究科(研究院), 教授 (10239189)
村瀬 晃平 名古屋大学, 工学(系)研究科(研究院), 准教授 (80298934)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 人工関節 / 炎症性サイトカイン / 表面テクスチャリング / 摩耗粉毒性 / 摩耗粉分析 / 超精密加工 / トライボロジー |
|---|
| Outline of Final Research Achievements |
In a polymer-on-hard artificial joint, the bearing parts are typically composed of an ultra-high molecular weight polyethylene and an alloy with good corrosion resistance, or polyethylene and a ceramic. Wear debris generated from the polyethylene part is considered a major factor in long-term osteolysis and loosening of artificial joints, because the presence of this debris stimulates macrophage activity, thereby promoting the production of cytokines. To control the specific wear rate and morphological features of wear debris of the polyethylene, micro slurry-jet erosion was used as a precision machining method for the bearing surface of a Co-Cr-Mo alloy. Pin-on-disc wear tests resulted in a decrease in the polyethylene wear and changes in the morphological features. Primary human peripheral blood mononuclear phagocytes were incubated with the debris, and the wear debris generated on the textured surface reduced the secretion of the IL-6 proinflammatory cytokines.
|
| Free Research Field |
バイオエンジニアリング
|
