Establishment of Cancer Therapy Using Pulsed High Electric Fields and the Development Based on Acceleration of In Vivo Experiments

2015 Fiscal Year Final Research Report

• Project/Area Number: 25289075
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Power engineering/Power conversion/Electric machinery
• Research Institution: The University of Tokushima
• Principal Investigator: Shimomura Naoyuki 徳島大学, ソシオテクノサイエンス研究部, 教授 (90226283)
• Co-Investigator(Kenkyū-buntansha): UTO Yoshihiro 徳島大学, ソシオテクノサイエンス研究部, 教授 (20304553) ; TERANISHI Kenji 徳島大学, ソシオテクノサイエンス研究部, 准教授 (80435403) ; YAMANAKA Kenji 徳島大学, ソシオテクノサイエンス研究部, 助教 (40641155)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: パルスパワー / がん治療 / パルス高電界 / アポトーシス / 発育鶏卵法

Outline of Final Research Achievements

To establish a new cancer therapy, techniques using pulsed high electric fields were studied. It has a potential to achieve a minimally invasive treatment because pulsed electric fields would induce programmed cell death as apoptosis.
By adopting the method of forming a solid tumor in a fertilized chicken egg, large number of animal test, which was usually high research cost, were performed. The growth suppression effect of the solid tumor by pulsed electric field was confirmed, and the effect was found to be dependent upon electric field strength. Moreover, the effect was mainly based on apoptosis. Three experiment systems were established eventually. Therefore, future research development is favorable.

Free Research Field

高電圧パルスパワー工学，パルスパワー応用