2015 Fiscal Year Final Research Report
Molecular basis of tactile response
| Project/Area Number |
25290008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | Aoyama Gakuin University (2014-2015)
National Institute of Genetics (2013) |
|---|
Principal Investigator |
Hirata Hiromi 青山学院大学, 理工学部, 教授 (60402450)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 遺伝学 / 神経科学 / 遺伝子 / 脳・神経 |
|---|
| Outline of Final Research Achievements |
We identified ring finger protein 121 (RNF121) as an endoplasmic reticulum-resident E3 ubiquitin ligase. The RNF121 regulates ubiquitination of voltage-gated sodium channel Nav1.6 and promotes its intracellular transport to a specific plasmamembrane region axon initial segment, where voltage-gated sodium channels form clusters. These results indicate that RNF121 is involved in the quality control of voltage-gated sodium channels and thus in mechanosensation and animal behavior.
|
| Free Research Field |
神経科学
|
