Analysis for epigenetic nechanims of genes selectively expressed in the primate neo cortex

2015 Fiscal Year Final Research Report

• Project/Area Number: 25290011
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Institute of Physical and Chemical Research (2015); National Institute for Basic Biology
• Principal Investigator: Yamamori Tetsuo 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80260206)
• Co-Investigator(Kenkyū-buntansha): Hata Katsusuke 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (20546692)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 大脳皮質 / 連合野 / 視覚野 / メチル化 / MBD4

Outline of Final Research Achievements

By large scale analysis of genes selectively expressed in certain area in the primate neocortex, we had reported that such genes could be classified two groups: One is high in the association areas and the other is high in the primary visual cortex. We examined the promoter region of representative association and primary visual area selective genes and found high and low methylation revels,respectively. Furthermore, we found that MBP4, a member of MBPs, can control the association area selective genes of PNMA5 and RBP4 by GOF (gain of function) and LOF (loss of function) analysis.

Free Research Field

分子脳科学