2016 Fiscal Year Final Research Report
Mechanisms of brain formation in higher mammals
| Project/Area Number |
25290013
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
Kawasaki Hiroshi 金沢大学, 脳・肝インターフェースメディシン研究センター, 教授 (50303904)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 大脳皮質 / 高等哺乳動物 |
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| Outline of Final Research Achievements |
The mechanisms underlying the formation of the brain of higher mammals have been of great interest. Here we examined the mechanisms of cortical folding using carnivore ferrets. We found that activation of FGF signaling resulted in polymicrogyria, and that SVZ progenitors mediated cortical folding. These results uncovered novel insights into the mechanisms of the formation of cortical folds and its diseases.
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| Free Research Field |
神経科学
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