Involvement of RNA editing of 5HT2C receptor in emotion and stress: functional and morphological study

2017 Fiscal Year Final Research Report

• Project/Area Number: 25290014
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: TANAKA Masaki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80264753)
• Co-Investigator(Kenkyū-buntansha): 田口 勝敏 京都府立医科大学, 医学(系)研究科(研究院), 助教 (60462701) ; 吉本 寛司 広島工業大学, 生命学部食品生命科学科, 教授 (70111903)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Yoshihisa 京都府立医科大学, 医学研究科, 講師 (50363990)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: 5-HT2C / RNA編集 / アルコール嗜好性 / 情動 / 側坐核

Outline of Final Research Achievements

Serotonin 2C (5-HT2C) receptor is expressed in the nervous system and involved in the emotion, stress and addiction. It is also known to undergo mRNA editing by adenosine deaminase acting on RNA type1 (ADAR1) and ADAR2 and make up to 24 isoforms and show the variety of epigenetic modification. During the period of receiving grants, we revealed that RNA editing of 5-HT2C receptor determines the alcohol preference in mice after chronic alcohol exposure using genetically modified mice. We also clarified that mice exclusively expressing non-edited type of 5-HT2C receptor isoform (INI type) showed desperate behavior and NPY neurons in the nucleus accumbens in the forebrain are involved in that behavior. Thus, we demonstrated that RNA editing of 5-HT2C receptor is related to alcohol preference and emotional behavior.

Free Research Field

神経科学