2016 Fiscal Year Final Research Report
Negative regulation of axonal myelination
Project/Area Number |
25290028
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | National Center for Child Health and Development |
Principal Investigator |
Yamauchi Junji 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 室長 (20335483)
|
Research Collaborator |
KAWAHARA KAZUKO 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 研究補助員
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | ミエリン形成 / 脱ミエリン現象 / 抑制シグナル / 促進シグナル / サイトヘジン / Arf6 / シグナル伝達分子 / 脱ミエリン疾患 |
Outline of Final Research Achievements |
It is believed that myelination in mammals is regulated by positive and negative signaling molecules; however, it remains to be understood what and how molecule controls myelination. Here we investigate inhibitory signaling for myelination in the peripheral nervous system. We clarify that the molecular pathway controlled by cytohesin regulates myelination. We also find that this pathway is composed of two reciprocal signaling pathways. Further studies allow us not only to understand the detailed mechanim of myelination but also to identify a potential therapeutic target for dismyelination desieases.
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Free Research Field |
神経薬理学
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