Elucidation of cooperative mechanisms between energy metabolism and stress response of cancer cells for drug discovery

2015 Fiscal Year Final Research Report

• Project/Area Number: 25290061
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Tomida Akihiro 公益財団法人がん研究会, がん化学療法センター ゲノム研究部, 部長 (40251483)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 癌 / 分子標的治療 / 微小環境 / グルコース / ストレス応答

Outline of Final Research Achievements

As cancer cells generally require a lot of glucose for proliferation, stress adaptation mechanisms coupled with energy metabolism play an essential role in cancer cell survival under tumor microenvironment where supply of glucose is not enough. In this study, we analyzed mitochondria-dependent and -independent mechanisms of cellular stress response under nutrient deprivation conditions, and found several regulatory proteins for each mechanism. We further evaluated the identified proteins as novel targets for drug discovery.

Free Research Field

分子細胞生物学