2015 Fiscal Year Final Research Report
Mechanism of genome DNA maintenance methylation
| Project/Area Number |
25291025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Tajima Shoji 大阪大学, たんぱく質研究所, 教授 (50132931)
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| Co-Investigator(Kenkyū-buntansha) |
SUETAKE ISAO 大阪大学, 蛋白質研究所, 准教授 (80304054)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | DNAメチル化 / DNAメチルトランスフェラーゼ / 維持メチル化 |
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| Outline of Final Research Achievements |
The CpG sequence in vertebrate genome is often methylated. DNA methylation is one of the factors that suppresses gene expression, and is crucial for development. DNA methylation patterns of genome are inherited to next generation during replication. DNA methyltransferase called Dnmt1 is responsible for faithful propagation of DNA methylation patterns. In the project we have provided structural and biochemical insights into the maintenance DNA methylation.
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| Free Research Field |
DNAメチル化の生化学
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