2016 Fiscal Year Final Research Report
Regulatory mechanisms of cellular functions by integrins and their ligands
Project/Area Number |
25291026
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
山田 雅司 大阪大学, たんぱく質研究所, 助教 (90304055)
二木 杉子 大阪大学, たんぱく質研究所, 助教 (00403014)
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Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 細胞外マトリックス / 細胞接着 / 幹細胞 / 細胞増殖 / ニッチ / リンパ管 |
Outline of Final Research Achievements |
Mice deficient of polydom, a newly identified integrin alpha9beta1 ligand, were generated to study the function of polydom. We found that i) polydom was secreted from mesenchymal cells and deposited around lymphatic vessels; ii) the lymphatic plexus failed to remodel into collecting lymphatic vessels in polydom-deficient mice and thereby died immediately after birth due to severe edema; iii) the expression of Foxc2, a transcription factor involved in lymphatic vessel remodeling, was reduced in polydom-deficient mice; iv) polydom was capable of binding to angiopoietin-2 that has been known to regulate lymphangiogenesis. These results indicate that polydom regulates lymphatic vessel remodeling through binding to angiopoietin-2, thereby promoting the expression of Foxc2.
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Free Research Field |
生化学・細胞生物学
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