2016 Fiscal Year Final Research Report
Elucidation of novel functions of GRWD1, a multifunctional protein with histone chaperone activity
| Project/Area Number |
25291027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 新規がん遺伝子 / 新規がん診断法 / GRWD1 / p53 / RPL11 / MDM2 |
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| Outline of Final Research Achievements |
Here, we show that GRWD1 is a novel oncogene that negatively regulates p53 via the RPL11-MDM2 and RPL23-MDM2 pathways. Furthermore, analyses of several cancer databases reveal that high expression of GRWD1 is associated with poor prognosis of patients suffering from certain cancers. It will become a useful diagnostic method for certain cancers to test the expression levels of GRWD1 in clinical samples. If novel compounds that can interfere with the interaction between GRWD1 and RPL11 (or RPL23) will be identified, they will be powerful novel anti-neoplastic agents.
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| Free Research Field |
分子生物学
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