2016 Fiscal Year Final Research Report
Elucidating mechanisms for microtubule formation and new functions of microtubules
Project/Area Number |
25291041
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Waseda University |
Principal Investigator |
Sato Masamitsu 早稲田大学, 理工学術院, 准教授 (50447356)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 微小管 / 細胞骨格 / 染色体 / 細胞分裂 / 減数分裂 |
Outline of Final Research Achievements |
We aimed to discover new cellular functions of the microtubule cytoskeleton in fission yeast. Our study discovered a new function of microtubules at the beginning of meiosis. The microtubule array interacts with kinetochores of chromosomes, thereby repositioning the arrangement of chromosomes in the nucleus after meiotic recombination. Importantly, the microtubule organization is essential for faithful chromosome segregation in meiosis. We also investigated molecular mechanisms as to how microtubules are organized in yeast cells. We found that the Alp7-Alp14 complex (MAPs) play pivotal roles in microtubule formation.
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Free Research Field |
細胞生物学
|