2015 Fiscal Year Final Research Report
Coordinated regulation of cell adhesion and growth through Rap1 signaling and mammalian Hippo pathway.
| Project/Area Number |
25291047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Yoshihiro 関西医科大学, 医学部, 講師 (90533208)
KONDO Naoyuki 関西医科大学, 医学部, 助教 (30570840)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Rap1 / Hippoシグナル / Mst1 / インテグリン / リンパ球 |
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| Outline of Final Research Achievements |
The Hippo pathway plays an important role in morphogenesis and cell proliferation. In this study, we investigated roles of the mammalian Hippo pathway in mice and humans, and revealed its novel roles in the immune system. The signal transduction through Rap1-RAPL -Mst1 /Mst2 (mammalian Hippo) were requisitely involved in the following processes; 1. thymic selections to eliminate self-reactive thymocytes, 2. antigen-specific adhesion of peripheral T cells to recognize foreign antigen, 3. antigen-specific suppressor functions of regulatory T cells, 4. the negative regulation of anti-tumor effects of cytotoxic T cells. These findings provide useful information to our understanding of inflammation, autoimmune, anti-tumor immunology and thereby development of therapeutics.
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| Free Research Field |
免疫学
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