Functional analysis of epigenetic intreating factors during heart regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 25291049
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: The University of Tokyo
• Principal Investigator: Takeuchi Jun 東京大学, 分子細胞生物学研究所, 准教授 (10451999)
• Co-Investigator(Renkei-kenkyūsha): KOSHIBA KAZUKO 東京大学, 分子細胞生物学研究所, 講師 (30467005) ; SHIRAHIGE KATSUHIKO 東京大学, 分子細胞生物学研究所, 教授 (90273854)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心臓再生 / エピジェネティック因子 / 運命決定 / 特定因子

Outline of Final Research Achievements

For mammalian heart regeneration or repair, we have reported about two factors during heart regeneration to JMCC (Morita et al., 2016a) and DGD (Nakamura et al., 2016). Sall1 which plays as a key factor for cardiac induction (Morita et al., JMCC 2016a) is also re-activated during heart regeneration (Morita et al., submitted 2016b). Baf60c has been identified as a key factor for cardiac formation (Koshiba-Takeuchi et al., Etiology and Morphogenesis of Congenital Heart Disease 2016; Takeuchi & Bruneau. Nature 2009) and also functions for heart regeneration (Nakamura et al., DGD 2016). These results will open the regenerative mechanisms in several organs for the basic science and will give us supportive idea for the heart repair in human.

Free Research Field

分子発生生物学