2016 Fiscal Year Final Research Report
Mechanisms controlling the multilevel polarity formation in the mouse oviduct
| Project/Area Number |
25291054
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | National Institute for Basic Biology |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
小林 徹也 東京大学, 生産技術研究所, 准教授 (90513359)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | マウス / 卵管 / 細胞極性 |
|---|
| Outline of Final Research Achievements |
Ovulated oocytes are transported in oviducts by unidirectional motility of multi-cilia and the resultant secretory fluid flow from ovary to uterus. The mammalian oviduct is highly polarized, where the epithelium forms longitudinal folds along the ovary-uterus axis, epithelial cells are elongated along the axis, and the epithelial multicilia beat towards the uterus to transport the ovulated ova. These cellular orientations in the oviduct are reflecting planar cell polarity (PCP). We studied mechanisms of the multilevel polarity formation process in the mouse oviduct by focusing on the function of PCP factors.
|
| Free Research Field |
発生生物学、細胞生物学
|
