2015 Fiscal Year Final Research Report
RNA and Amino Acid: Elucidation of the Mystery of the Asymmetry of Life
| Project/Area Number |
25291082
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TAMURA Koji 東京理科大学, 基礎工学部, 教授 (30271547)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | RNA / アミノ酸 / ホモキラリティー / 起源 |
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| Outline of Final Research Achievements |
In order to elucidate the origin of the asymmetry of life on Earth (nucleic acids are composed of D-sugars, whereas proteins are composed of L-amino acids), I focused on the process of tRNA aminoacylation that is the first encounter step between RNAs and amino acids. The model molecule synthesis based on “chiral-selective aminoacylation of RNA”, which I discovered in 2004, for the purpose of performing X-ray crystallography was successful. In addition, comparison of the energies of the final products of the reaction was done by using molecular dynamics. I also found the change of the viscosity of nucleotide solution containing cyanuric acid.
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| Free Research Field |
生体物質化学
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