Molecular mechanisms of signaling pathways regulating inflammatory responses and their elucidation by bioprobes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25292061
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied biochemistry
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: KATAOKA Takao 京都工芸繊維大学, その他部局等, 教授 (20242307)
• Co-Investigator(Renkei-kenkyūsha): USUI Takeo 筑波大学, 生命環境系, 准教授 (60281648)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 炎症性サイトカイン / バイオプローブ / 情報伝達 / NF-κB / イルシニアスタチンA / アラントピロンA / トリテルペノイド / カルデノリドアグリコン

Outline of Final Research Achievements

Cytokine receptors regulating inflammatory responses activate the transcription factor nuclear factor κB (NF-κB) signaling pathway by various adaptor proteins and protein kinases. The NF-κB pathway induces the transcription of many genes, such as those encoding cytokines, chemokines, and adhesion molecules, and regulates inflammatory responses by their gene expression. In this study, the molecular mechanisms of the signaling pathways and gene expression induced by inflammatory cytokines were elucidated largely by using small molecules as bioprobes.

Free Research Field

細胞生物学