Studies on the modulation of biological functions by food factors through the action of aryl hydrocarbon receptor

2015 Fiscal Year Final Research Report

• Project/Area Number: 25292072
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Kobe University
• Principal Investigator: Ashida Hitoshi 神戸大学, (連合)農学研究科(研究院), 教授 (90201889)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アリール炭化水素受容体 / ダイオキシン / ポリフェノール / ケンフェロール / クルクミン / ルテオリン / 薬物代謝 / 脂肪細胞分化

Outline of Final Research Achievements

In this study, we investigated the functions of polyphenols on an aryl hydrocarbon receptor (AhR)-dependent actions. We obtained following findings: (1) Luteolin, kaempferol, curcumin, and procyanidin suppressed TCDD (an AhR agonist)-induced expression of drug-metabolizing enzymes through inhibition of AhR transformation; (2) Luteolin canceled TCDD-inhibited adipocyte differentiation through suppression of AhR nuclear translocation; (3) Luteolin, kaempferol, and curcumin rapidly incorporated into hepatocytes and adipocytes as mainly an aglyconefom, and thereafter they modulated AhR-dependent actions; and (4) Chalcones such as cardamonin suppressed AhR transformation. These results indicate that certain polyphenols possess multi-functional suppressive effect against AhR-dependent actions for the toxicities of TCDD.

Free Research Field

食品科学