2016 Fiscal Year Final Research Report
Elucidating the mechanism of fat accumulation in skeletal muscle and its pathophysiological significance.
| Project/Area Number |
25292185
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 骨格筋 / 脂肪細胞 / 線維芽細胞 / 間葉系前駆細胞 / CSPG4 / ジストロフィン / 筋分化 / 脂肪分化 |
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| Outline of Final Research Achievements |
In some pathologies such as sarcopenia and muscular dystrophy, fat accumulation (appearance of adipocytes) is seen in skeletal muscle. The accumulated adipocytes are considered to affect skeletal muscle function. The present study was undertaken to elucidate the mechanism of fat accumulation and its pathophysiological significance. We have identified chondroitin sulfate proteoglycan 4 (CSPG4) as a molecule involved in adipogenic and fibrogenic differentiation of mesenchymal progenitor cells. In addition, we have succeeded in generating lines of novel muscular dystrophy model rats by genome editing.
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| Free Research Field |
獣医生理学
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