Discovery of new reactions and utilities of 4-membered carbocyles based on their unique ring strains.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293002
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: TAKASU KIYOSEI 京都大学, 薬学研究科(研究院), 教授 (10302168)
• Co-Investigator(Kenkyū-buntansha): HATTORI Akira 京都大学, 大学院薬学研究科, 准教授 (50300893) ; YAMAOKA Yousuke 京都大学, 大学院薬学研究科, 助教 (60624723)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 有機合成 / 分子ひずみ / シクロブタン / 中員環 / 天然物合成 / 機能性分子 / 反応開発

Outline of Final Research Achievements

Four-membered carbocyclic ring systems, including cyclobutanes and cyclobutenes, are one of fundamental and important structural units. Four-membered ring compounds are frequently found in natural and unnatural products displaying unique biological activities. In addition, cyclobutanes and cyclubutenes have been utilized as key intermediates in synthetic routes producing structurally complex targets because of their unique chemical transformation such as ring-opening and ring-expansion reactions. Despite their high utility, only a limited number of practical and efficient methods exist for their synthesis. We found several new chemistry of cyclobutanes, cyclobutenes and related substances. We also demonstrated its synthetic application to biologically active substances having 4-membered carbocyles.

Free Research Field

有機合成、構造化学