Immunosuppressive role of lysophosphatidylserine and its evaluation as drug targets

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293010
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Aoki Junken 東北大学, 薬学研究科(研究院), 教授 (20250219)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: リゾホスファチジルセリン / GPCR / 作動薬 / 免疫抑制

Outline of Final Research Achievements

Previously we isolated two GPCR, P2Y10 and GPR174, as specific receptor for lysophospholipid mediator, lysophosphatidylserine (LysoPS). In this study, by analyzing knockout mice of P2Y10 and GPR174, we tried to identify the pathophysiological roles of LysoPS through these receptors. In addition, we tried to create specific agonist as drug candidates. First we found that both P2Y10 and GPR174 KO mice showed enlarged lymphonodes and spleen with enhanced proliferation of T and B lymphocytes. By chemically modifying each chemical group of LysoPS, we succeeded in identifying specific agonists for each receptor, which showed 1,000 times more activity than LysoPS.

Free Research Field

脂質生物学