2015 Fiscal Year Final Research Report
Study on the regulation of cardiac homeostasis by formation of TRPC3/6 channel protein complex
| Project/Area Number |
25293018
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Okazaki Research Facilities, National Institutes of Natural Sciences |
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Principal Investigator |
Nishida Motohiro 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90342641)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 心血管疾患 / チャネル / 恒常性 / 活性酸素 / 創薬 / レジリエンス |
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| Outline of Final Research Achievements |
Human living activity is maintained by systemic and pulmonary blood circulation, and muscular cells, including cardiomyocytes, vascular smooth muscle cells, and skeltal muscle cells, predominantly support this system. We focused on transient receptor potential canonical 3 and 6 heterotetramer channels (TRPC3/6), a non-selective cation-permeable channel that regualtes resting membrane potential in cells, and found that inhibition of TRPC3/6 channel activities in muscular cells will be a new strategy for the prevention of our cardiovascular system from ischemic and hypertensive stresses, using mouse models for human cardiovascular diseases.
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| Free Research Field |
薬理学
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