2017 Fiscal Year Final Research Report
Discovery of antitumor drug candidates from rainforest plants
| Project/Area Number |
25293024
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kanazawa University |
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Principal Investigator |
Goto Kyoko 金沢大学, 薬学系, 准教授 (50180245)
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| Co-Investigator(Kenkyū-buntansha) |
三宅 克典 東京薬科大学, 薬学部, 助教 (20597687)
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| Research Collaborator |
GOTO Masuo Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Research Professor
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | 熱帯雨林産植物 |
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| Outline of Final Research Achievements |
Over 60 of novel natural products were isolated from six rainforest plant extracts, which were provided by National Cancer Institute in USA. Among them, the potent antitumor compounds were selected and constructed their total synthetic routes. Further preparations of their derivatives and study of structure-activity relationship were carried out.
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| Free Research Field |
創薬天然物化学
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