2015 Fiscal Year Final Research Report
Search for drug leads of autoimmune disease targeting the immunoproteasome
| Project/Area Number |
25293025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOSAWA Hideyoshi 愛知学院大学, 薬学部, 教授 (90012765)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 免疫プロテアソーム / 自己免疫疾患 / 創薬 / 天然資源 |
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| Outline of Final Research Achievements |
The immunoproteasome plays an important role in antigen processing and T cell generation. Recently, immunoproteasome-specific inhibitors have been proposed to have effects on diseases including immune function. In this study, we searched for selective immunoproteasome inhibitors from natural sources. In screening, we selected the extracts of natural sources that inhibited the immunoproteasome more potent than the constitutive proteasome and purified inhibitors. We succeeded in isolating new proteasome inhibitors, whereas they were found to be non-selective inhibitors.
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| Free Research Field |
天然物化学
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