Development of renoprotective and uremia therapeutic drug seeds based on inhibition of hepatic production of sulfate-conjugated uremic solutes

2016 Fiscal Year Final Research Report

• Project/Area Number: 25293040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: Saito Hideyuki 熊本大学, 医学部附属病院, 教授 (40225727)
• Co-Investigator(Kenkyū-buntansha): 西 一彦 熊本大学, 医学部附属病院, 准教授 (30264287) ; 城野 博史 熊本大学, 医学部附属病院, 准教授 (40515483)
• Research Collaborator: SAIGO Chika ; SAGATA Masataka
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 薬物動態 / 代謝スクリーニング / 尿毒症物質 / 腎臓病 / 硫酸転移酵素 / 急性腎障害

Outline of Final Research Achievements

This research was aimed to explore specific inhibitors of hepatic production of indoxyl sulfate, a sulfate-conjugated uremic solute, taht are involved in renal dysfuntion and acute kidney injury associated with uremia. By using the screening system for indoxyl sulfate production, we found that polyphenolic compounds and fenmic acid agent had potent inhibitory effects on hepatic indoxyl sulfate production. Administration of these polyphenols to rats with acute kidney injury ameliorated the disturbed renal function, suggesting that these approaches could be a useful strategy to develop therapeutic drugs for kidney injuries and/or dieases with uremia.

Free Research Field

臨床薬物動態学分野