Crosstalk between fat metabolism and insulin signaling in glucose homeostasis: Analysis in fat-sensitive diabetes mice

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293051
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Chiba University
• Principal Investigator: Miki Takashi 千葉大学, 医学(系)研究科(研究院), 教授 (50302568)
• Co-Investigator(Kenkyū-buntansha): MUKAI Eri 千葉大学, 大学院医学研究院, 講師 (60362539) ; LEE Eun Young 千葉大学, 大学院医学研究院, 助教 (60583424)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖尿病 / 栄養学 / 胆汁酸

Outline of Final Research Achievements

The rapid increase in the number of patients with type 2 diabetes mellitus is considered to be due, at least in part, to excessive fat intake. However, the lack of animal model of high fat diet (HFD)-induced diabetes has hampered the elucidation of its underlying mechanism. We found that the insulin receptor mutant mice (mIR mice) develop overt hyperglycemia only under HFD feeding. Our pathophysiological analyses of mIR mice under HFD (mIR/HFD mice) revealed that unsuppressed lipolysis plus increased gluconeogenesis from glycerol evokes hyperglycemia and that bile acid physiology is markedly altered in mIR/HFD mice.

Free Research Field

代謝生理学