Multimodal GABA systems responding to environmental stress

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293052
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Fukuda Atsuo 浜松医科大学, 医学部, 教授 (50254272)
• Co-Investigator(Renkei-kenkyūsha): AKITA TENPEI 浜松医科大学, 医学部, 准教授 (00522202) ; WATANABE MIHO 浜松医科大学, 医学部, 助教 (10399321) ; HATA KENICHIRO 国立成育医療研究センター, 部長 (60360335) ; MURAKAMI GEN 浜松医科大学, 医学部, 研究員 (70613727)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: GAD67 / タウリントランスポーター / HPA / 神経発生 / GABA / タウリン / 母体ストレス / メチル化

Outline of Final Research Achievements

We had got interested in the Cl- homeodynamics and multimodal GABA actions at genes, cells, and neural network levels. We have investigated, by means of maternal restraint stress GAD67 heterozygous mouse models and taurine transporter (TauT) knock-out (KO) mice, GABA actions on hypothalamic CRH cells in dams as well as neurogenesis, migration, synaptic activities, placental function, HPA axis responses and behavioral responses in pups. We have found multimodal GABA-related molecules responding to GAD67 impairment and restraint stress including their DNA methylation, such as involved in neurogenesis, migration, and synaptic plasticity of GABA neurons and HPA axis activation.

Free Research Field

医歯薬学