2015 Fiscal Year Final Research Report
The role of ROS in spermatogonial stem cell self-renewal
| Project/Area Number |
25293067
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
SHINOHARA Takashi 京都大学, 医学(系)研究科(研究院), 教授 (30322770)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 精子幹細胞 |
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| Outline of Final Research Achievements |
In this study, we analyzed the role of reactive oxygen species (ROS) in spermatogonial stem cell self-renewal. Because it has been considered that ROS is detrimental to germ cells, reduction of ROS is often used as a therapy for male infertility treatment. However, we found that spermatogonial stem cells in Nox1 deficient mice show significantly reduced self-renewal division. Moreover, we also showed that Nox3, another member of the Nox gene family, also plays an important role in the initiation of self-renewal division. These results suggested that ROS are required for spermatogonial stem cell renewal.
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| Free Research Field |
生殖生物学
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