2017 Fiscal Year Final Research Report
Integrated understanding of quality control, membrane insertion, and membrane fusion of SNARE proteins
| Project/Area Number |
25293071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山本 泰憲 神戸大学, 医学研究科, 准教授 (30467659)
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | 小胞輸送 / SNAREタンパク質 / 品質管理 / 膜挿入 / 膜融合 |
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| Outline of Final Research Achievements |
Vesicle traffic plays important roles in various cellular events, such as exocytosis of hormone or digestive enzyme, and endocytosis of growth factor. SNARE proteins are essential for vesicle traffic. The amount of v-SNARE proteins on the vesicle and the amount of t-SNARE proteins on the target membrane regulate the speed of vesicle fusion. We have identified membrane insertion complex for SNARE proteins, CAML complex. To elucidate regulatory mechanism of membrane insertion of SNARE proteins, we identified p47 as a CAML-interacting protein. We also revealed subcellular localization mechanism of a SNARE protein lacking SNARE motif, Sec22c.
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| Free Research Field |
医化学一般
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