Multi-step carcinogenesis due to non-coding repetitive RNA expression

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293076
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Otsuka Motoyuki 東京大学, 医学部附属病院, 助教 (90518945)
• Co-Investigator(Kenkyū-buntansha): IJICHI Hideaki 東京大学, 医学部附属病院, 講師 (70463841) ; MAEDA Shin 横浜市立大学, 医学系研究科, 教授 (40415956)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 分子腫瘍学 / 非コードRNA / ミトコンドリア

Outline of Final Research Achievements

While oncogenesis is a process with multi-step mutations of oncogenes and tumor suppressor genes, the molecular mechanisms why and how such mutations accumulate during the carcinogenesis steps. In this stuudy, it was revealed that non-coding repetitive RNA, which express at the early phase of carcinogenesis, binds to YB-1, a repair gene, and suppresses its function. Due to this, mutations of genomic DNA and mitochondrial DNA accumulate and the intracellualr circumstances are disturbed, which leads to carcinogenesis. Based on these results, intervention to inhibit the binding between reprtitive RNA and YB1 may be useful for the supression of carcinogenesis steps.

Free Research Field

医歯薬学