A novel model of signal transduction according to transcripts

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293090
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Yatabe Yasushi 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (90280809)
• Co-Investigator(Kenkyū-buntansha): SAKAO YUKINORI 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (00274605)
• Co-Investigator(Renkei-kenkyūsha): HIDA TOYOAKI 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (80250249)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肺癌 / 分子病理学 / 腺癌 / EGFR / KRAS / 腫瘍進展

Outline of Final Research Achievements

We focused on the following four themes in this study.
1) A novel model of signal transduction according to transcripts: We found HNF4a functioned as a master regulator for invasive mucinous adenocarcinoma. Also, a novel fusion involving NRG1 was identified in this subtype. 2) Non-stepwise model of lung adenocarcinoma development: We had some findings that supported no-stepwise progression using preinvasive lesions. 3) Genetic heterogeneity of cancer: We analyzed discordant results between protein expression and gene rearrangement of a driver gene for the lung, ALK. 4) Diagnostic application of molecular findings: We contributed to generate guidelines for molecular testing and formulation of basic data for primary-unknown cancers.

Free Research Field

分子腫瘍病理学