2015 Fiscal Year Final Research Report
Development of the molecular targeted therapy for allergic dermatitis
| Project/Area Number |
25293091
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
|
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| Research Institution | University of Tsukuba |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 免疫系受容体 / アレルギー性皮膚炎 / costimulatory 分子 / ヘルパーT細胞分化 / 分子標的療法 |
|---|
| Outline of Final Research Achievements |
Although Th1 and Th2 cells are known to be involved in allergic inflammatory diseases, the molecular mechanisms underlying their differentiation are incompletely understood. Here, we identified CD155 as a costimulatory molecule on CD4+ T cells. CD155-mediated signaling induced Th1 development. Mice treated with anti-CD155 antibody exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T-cell differentiation and allergic diseases.
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| Free Research Field |
免疫学、臨床免疫学
|
