2015 Fiscal Year Final Research Report
Roles of TGF-beta target genes TMEPAI and MafK on cancer development
| Project/Area Number |
25293092
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Yukihide 筑波大学, 医学医療系, 助教 (40618534)
OKITA Yukari 筑波大学, 医学医療系, 研究員 (30743710)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | がん / 足場非依存性増殖 / がん幹細胞 / トランスフォーミング増殖因子β |
|---|
| Outline of Final Research Achievements |
Transforming Growth Factor-β (TGF-β) was discovered as a factor expressed by oncogenes and induces anchorage-independent soft agar colony formation together with TGF-α. In this study, we identified TMEPAI and MafK as target genes expressed by TGF-β and induces anchorage-independent growth and tumor formation. TMEPAI suppresses TGF-β/Smad signaling and activates AKT. MafK induces epithelial-mesenchymal transition and transmembrane glycoprotein GPNMB. These activities are essential for their tumorigenic activities. We further made antibodies for TMEPAI and MafK for further clinic-pathological studies.
|
| Free Research Field |
実験病理学、腫瘍学
|
