2015 Fiscal Year Final Research Report
Regulatory mechanism of inflammation and inflammation-related cancer by regulating Ras-Raf-ERK/MAPK
| Project/Area Number |
25293095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Toshihiro 岡山大学, 大学院医歯薬学総合研究科, 講師 (00595712)
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| Research Collaborator |
TAKAHASHI Sakuma
FUSHIMI Soichiro
TAIRA Asako
ITAKURA Junya
WATANABE Haruyuki
SATO Miwa
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 炎症 / シグナル伝達・抑制 / 炎症とがん |
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| Outline of Final Research Achievements |
In this project, we have analyzed the role of Ras-Raf-ERK/MAPK and its endogenous inhibitor, Spred-2 in various animal models, using Spred-2 knock-out (KO) mice. We have demonstrated that Spred-2 plays a central role in the regulation of inflammation in various types of inflammation. Our results suggest that Spred-2 can be a new target for controlling inflammation. We also demonstrated that Spred-2 expressed in clinical cancer tissue may be involved carcinogenesis and cancer progression. Furthermore, our results indicate that Spred-2 may be essential regulator of cancer metastasis by modulating epithelial mesenchymal transition (EMT).
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| Free Research Field |
実験病理学
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