2017 Fiscal Year Final Research Report
Analysis of VZV latency induced by antigenic modulation
| Project/Area Number |
25293108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | University of Toyama |
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Principal Investigator |
Shiraki Kimiyasu 富山大学, 大学院医学薬学研究部(医学), 教授 (50135745)
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| Co-Investigator(Renkei-kenkyūsha) |
DAIKOKU Tohru 北陸大学, 薬学部, 教授 (80291409)
TAKEMOTO Masaya 北陸大学, 薬学部, 講師 (60379237)
YAJIMA Misako 東北医科薬科大学, 医学部, 助教 (60443131)
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| Research Collaborator |
KUROSA Yoshikazu
ASANO Yoshizo
SUZUKI Yasuhiko
OHNO Ayumu
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Keywords | 水痘帯状疱疹ウイルス / 抗原変調 / 潜伏感染 |
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| Outline of Final Research Achievements |
Treatment with neutralizing antibody against varicella-zoster virus of infected cell induced antigenic modulation leading to latent state similar to the latency in neurons. Colocalization of the immediate early proteins and the transcription factor SP1 in untrated infected cells was altered by the antigenic modulation. Buthionine sulfoximine (BSO) treatment slowed the disappearance of their colocalization from the nucleus and prevented latent infection. Furthermore, Viral DNA become chromatin-associated status in latent infection, but BSO increased the amounts of chromainted free viral DNA.
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| Free Research Field |
ウイルス学
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