2017 Fiscal Year Final Research Report

Classification and alternative methods for sensitizers

Research Project

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Project/Area Number	25293148
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Partial Multi-year Fund
Section	一般
Research Field	Hygiene and public health
Research Institution	University of Fukui
Principal Investigator	Sato Kazuhiro 福井大学, 学術研究院医学系部門, 准教授 (40262620)
Co-Investigator(Kenkyū-buntansha)	土橋邦生群馬大学, 大学院保健学研究科, 教授 (00241894) 皆本景子熊本大学, 大学院生命科学研究部(医), 助教 (00381012) 稲寺秀邦富山大学, 大学院医学薬学研究部(医学), 教授 (10301144) 梅村朋弘愛知医科大学, 医学部, 講師 (10401960) 竹下達也和歌山県立医科大学, 医学部, 教授 (20150310) 大槻剛巳川崎医科大学, 医学部, 教授 (40160551) 中平浩人新潟青陵大学, 看護学部, 教授 (40217758) 亀尾聡美群馬大学, 大学院医学系研究科, 助教 (40312558) 中地重晴熊本学園大学, 社会福祉学部, 教授 (50586849) 金山ひとみ福井大学, 学術研究院医学系部門, 助教 (60377249) 日下幸則福井大学, 学術研究院医学系部門, 教授 (70135680) 吉田貴彦旭川医科大学, 医学部, 教授 (90200998) 柴田英治愛知医科大学, 医学部, 准教授 (90206128) 福島哲仁福島県立医科大学, 医学部, 教授 (90208942) 田村太朗福井大学, 学術研究院医学系部門, 助教 (90509291) 青山公治鹿児島大学, 医学部, 講師 (70117472) 上田厚熊本大学, その他の研究科, 名誉教授 (10040198)
Project Period (FY)	2013-04-01 – 2018-03-31
Keywords	アレルギー・ぜんそく
Outline of Final Research Achievements	Contact dermatitis is by far the most common form of occupational skin illness. In silico assessment of skin sensitization is increasingly needed owing to the problems concerning animal welfarre, as well as excessive time consumed and cost involved in the development and testing of new chemicals. We made skin sensitization QSTRb model from only animal data (LLLNA) by using K step Yard sampling (KY) method (US Paten No, 7725413, 2010) and 1 model KY method (US Pantent Application) and performed external validation studies. We made QSTR model based on EC3 of LLNA to discriminate between strong and weak sensitizers and QSTR. Second alert constituents of the data were analyzed by filtering (selective determination). Skin sensitizers which are indexed in German MAK and are not indexed in JOH are proposed to OEL committeee with review artocles and approved.
Free Research Field	衛生学